Publications

Papers in scientific journals

Michel Bernier, Ignacio Navas Enamorado, Mari Carmen Gómez-Cabrera, Miguel Calvo-Rubio, Jose Antonio González-Reyes, Nathan L. Price, Ana Belén Cortés-Rodríguez, Juan Carlos Rodríguez-Aguilera, Sandra Rodríguez-López, Sarah J. Mitchell, Kelsey N. Murt, Krystle Kalafut, Katrina M. Williams, Christopher W. Ward, Joseph P. Stains, Gloria Brea-Calvo, Jose M. Villalba, Sonia Cortassa, Miguel A. Aon and Rafael de Cabo.  Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice. npj Aging 2022; 8, 8. https://doi.org/10.1038/s41514-022-00089-8

Carlos Santos‐Ocaña, María V. Cascajo, María Alcázar‐Fabra, Carmine Staiano, Guillermo López‐Lluch, Gloria Brea‐Calvo and Plácido Navas; Cellular Models for Primary CoQ Deficiency Pathogenesis Study. International Journal of Molecular Science. 2021 Sept; 22, 10211. doi: 10.3390/ijms221910211

Navas P, Cascajo MV, Alcázar-Fabra M, Hernández-Camacho JD, Sánchez-Cuesta A, Rodríguez ABC, Ballesteros-Simarro M, Arroyo-Luque A, Rodríguez-Aguilera JC, Fernández-Ayala DJM, Brea-Calvo G, López-Lluch G, Santos-Ocaña C.; Secondary CoQ10 deficiency, bioenergetics unbalance in disease and aging. Biofactors. 2021 Apr 20; 1-19. doi: 10.1002/biof.1733

Alcázar-Fabra M, Rodríguez-Sánchez F, Trevisson E, Brea-Calvo G. Primary Coenzyme Q deficiencies: A literature review and online platform of clinical features to uncover genotype-phenotype correlations. Free Radic Biol Med. 2021 Mar 4;167:141-180. doi: 10.1016/j.freeradbiomed.2021.02.046

Pérez-Pulido AJ, Asencio-Cortés G, Brokate-Llanos AM, Brea-Calvo G, Rodríguez-Griñolo R, Garzón A, Muñoz MJ. Serial co-expression analysis of host factors from SARS-CoV viruses highly converges with former high-throughput screenings and proposes key regulators. Briefings in Bioinformatics. 2021 Jan 18; bbbaa419. doi: 10.1093/bib/bbaa419

Luna-Sanchez M, Benincá C, Cerutti R, Brea-Calvo G, Yeates A, Scorrano L, Zeviani M, Viscomi C. Opa1 Overexpression Protects from Early-Onset Mpv17-/–Related Mouse Kidney Disease. Mol Ther. 2020 Aug 5;28 (8):1918-1930. doi: 10.1016/j.ymthe.2020.06.010.

Dhandapani PK, Begines-Moreno IM, Brea-Calvo G, Gärtner U, Graeber TG, Javier Sanchez G, Morty RE, Schönig K, Hoeve JT, Wietelmann A, Braun T, Jacobs HT, Szibor M. Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy. Sci Rep.2019 Sep 4;9(1):12741. doi: 10.1038/s41598-019-49231-9.

Vázquez-Fonseca L, Schaefer J, Navas-Enamorado I, Santos-Ocaña C, Hernández-Camacho JD, Guerra I, Cascajo MV, Sánchez-Cuesta A, Horvath Z, Siendones E, Jou C, Casado M, Gutiérrez P, Brea-Calvo G, López-Lluch G, Fernández-Ayala DJM, Cortés-Rodríguez AB, Rodríguez-Aguilera JC, Matté C, Ribes A, Prieto-Soler SY, Dominguez-Del-Toro E, Francesco AD, Aon MA, Bernier M, Salviati L, Artuch R, Cabo R, Jackson S, Navas P. ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency. J Clin Med. 2019 Sep 2;8(9):1374. doi: 10.3390/jcm8091374.

Acosta Lopez MJ, Trevisson E, Canton M, Vazquez-Fonseca L, Morbidoni V, Baschiera E, Frasson C, Pelosi L, Rascalou B, Desbats MA, Alcázar-Fabra M, Ríos JJ, Sánchez-García A, Basso G, Navas P, Pierrel F, Brea-Calvo G*, Salviati L. Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6.Oxid Med Cell Longev. 2019 Jul 10;2019:3904905. doi: 10.1155/2019/3904905. (*co-corresponding)

Ling TK, Law CY, Yan KW, Fong NC, Wong KC, Lee KL, Chu WC, Brea-Calvo G, Lam CW. Clinical whole-exome sequencing reveals a common pathogenic variant in patients with CoQ10 deficiency: An underdiagnosed cause of mitochondriopathy. Clin Chim Acta. 2019 Oct;497:88-94. doi: 10.1016/j.cca.2019.07.016.

Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C. Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy. Cell Metab. 2018 Nov 6;28(5):764-775.e5. doi: 10.1016/j.cmet.2018.07.012.

Alcázar-Fabra M, Trevisson E and Brea-Calvo G. Clinical syndromes associated with Coenzyme Q10 deficiency. Essays Biochem. 2018 Jul 20;62(3):377-398. doi: 10.1042/EBC20170107.

Navas-Enamorado I, Bernier M, Brea-Calvo G, de Cabo R. Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle. Ageing Res Rev. 2017 Aug;37:39-52. doi: 10.1016/j.arr.2017.04.005.

Yubero D, Montero R, Martín MA, Montoya J, Ribes A, Grazina M, Trevisson E, Rodriguez-Aguilera JC, Hargreaves IP, Salviati L, Navas P, Artuch R; CoQ deficiency study group, Jou C, Jimenez-Mallebrera C, Nascimento A, Pérez-Dueñas B, Ortez C, Ramos F, Colomer J, O’Callaghan M, Pineda M, García-Cazorla A, Espinós C, Ruiz A, Macaya A, Marcé-Grau A, Garcia-Villoria J, Arias A, Emperador S, Ruiz-Pesini E, Lopez-Gallardo E, Neergheen V, Simões M, Diogo L, Blázquez A, González-Quintana A, Delmiro A, Domínguez-González C, Arenas J, García-Silva MT, Martín E, Quijada P, Hernández-Laín A, Morán M, Rivas Infante E, Ávila Polo R, Paradas Lópe C, Bautista Lorite J, Martínez Fernández EM, Cortés AB, Sánchez-Cuesta A, Cascajo MV, Alcázar M, Brea-Calvo G. Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders.Mitochondrion. 2016 Sep;30:51-8. doi: 10.1016/j.mito.2016.06.007.

Alcázar-Fabra M, Navas P, Brea-Calvo G. Coenzyme Q biosynthesis and its role in the respiratory chain structure. Biochim Biophys Acta. 2016 Aug;1857(8):1073-1078. doi: 10.1016/j.bbabio.2016.03.010.

Brea-Calvo G, Haack TB, Karall D, Ohtake A, Invernizzi F, Carrozzo R, Kremer L, Dusi S, Fauth C, Scholl-Bürgi S, Graf E, Ahting U, Resta N, Laforgia N, Verrigni D, Okazaki Y, Kohda M, Martinelli D, Freisinger P, Strom TM, Meitinger T, Lamperti C, Lacson A, Navas P, Mayr JA, Bertini E, Murayama K, Zeviani M, Prokisch H, Ghezzi D. COQ4 mutations cause a broad spectrum of mitochondrial disorders associated with CoQ10 deficiency. Am J Hum Genet. 2015 Feb 5;96(2):309-17. doi: 10.1016/j.ajhg.2014.12.023.

Cascajo MV, Abdelmohsen K, Noh JH, Fernández-Ayala DJ, Willers IM, Brea-Calvo G, López-Lluch G, Valenzuela-Villatoro M, Cuezva JM, Gorospe M, Siendones E, Navas P. RNA-binding proteins regulate cell respiration and coenzyme Q biosynthesis by post-transcriptional regulation of COQ7. RNA Biol. 2016 Jul 2;13(7):622-34. doi: 10.1080/15476286.2015.1119366.

Dalla Rosa I, Durigon R, Pearce SF, Rorbach J, Hirst EM, Vidoni S, Reyes A, Brea-Calvo G, Minczuk M, Woellhaf MW, Herrmann JM, Huynen MA, Holt IJ, Spinazzola A. MPV17L2 is required for ribosome assembly in mitochondria. Nucleic Acids Res. 2014 Jul;42(13):8500-15. doi: 10.1093/nar/gku513.

Johnson MA, Vidoni S, Durigon R, Pearce SF, Rorbach J, He J, Brea-Calvo G, Minczuk M, Reyes A, Holt IJ, Spinazzola A. Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.  PLoS One. 2014 Apr 9;9(4):e93597. doi: 10.1371/journal.pone.0093597.

Kazak L, Reyes A, He J, Wood SR, Brea-Calvo G, Holen TT, Holt IJ. A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties. PLoS One. 2013 May 13;8(5):e62340. doi: 10.1371/journal.pone.0062340.

Kazak L, Reyes A, Duncan AL, Rorbach J, Wood SR, Brea-Calvo G, Gammage PA, Robinson AJ, Minczuk M, Holt IJ. Alternative translation initiation augments the human mitochondrial proteome. Nucleic Acids Res. 2013 Feb 1;41(4):2354-69. doi: 10.1093/nar/gks1347.

Brea-Calvo G, Siendones E, Sánchez-Alcázar JA, de Cabo R, Navas P. Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis.PLoS One. 2009;4(4):e5301. doi: 10.1371/journal.pone.0005301.

Sánchez-Alcázar JA, Rodríguez-Hernández A, Cordero MD, Fernández-Ayala DJ, Brea-Calvo G, Garcia K, Navas P. The apoptotic microtubule network preserves plasma membrane integrity during the execution phase of apoptosis. Apoptosis. 2007 Jul;12(7):1195-208. doi: 10.1007/s10495-006-0044-6.

Artuch R, Brea-Calvo G, Briones P, Aracil A, Galván M, Espinós C, Corral J, Volpini V, Ribes A, Andreu AL, Palau F, Sánchez-Alcázar JA, Navas P, Pineda M. Cerebellar ataxia with coenzyme Q10 deficiency: diagnosis and follow-up after coenzyme Q10 supplementation. J Neurol Sci. 2006 Jul 15;246(1-2):153-8. doi: 10.1016/j.jns.2006.01.021.

Brea-Calvo G, Rodríguez-Hernández A, Fernández-Ayala DJ, Navas P, Sánchez-Alcázar JA. Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines. Free Radic Biol Med. 2006 Apr 15;40(8):1293-302. doi: 10.1016/j.freeradbiomed.2005.11.014.

Rodríguez-Hernández A, Brea-Calvo G, Fernández-Ayala DJ, Cordero M, Navas P, Sánchez-Alcázar JA. Nuclear caspase-3 and caspase-7 activation, and poly-(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis. Apoptosis. 2006 Jan;11(1):131-9. doi: 10.1007/s10495-005-3276-y.

Fernández-Ayala DJ, Brea-Calvo G, López-Lluch G, Navas P. Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system. Biochim Biophys Acta. Biomembranes. 2005 Jul 30;1713(2):129-37. doi: 10.1016/j.bbamem.2005.05.010.

Sánchez-Alcázar JA, Bradbury DA, Brea-Calvo G, Navas P, Knox AJ. Camptothecin-induced apoptosis in non-small cell lung cancer is independent of cyclooxygenase expression. Apoptosis. 2003 Dec;8(6):639-47. doi: 10.1023/A:1026147812000.

Proietti De Santis L, Garcia CL, Balajee AS, Brea Calvo GT, Bassi L, Palitti F. Transcription coupled repair deficiency results in increased chromosomal aberrations and apoptotic death in the UV61 cell line, the Chinese hamster homologue of Cockayne’s syndrome B. Mutat Res. 2001 Mar 7;485(2):121-32. doi: 10.1016/s0921-8777(00)00065-3.

Barbara Tomassini, Florence Malisan, Luigi Franchi, Chiara Nicolò, Gloria Brea Calvo, Takashi Saito, Roberto Testi. Calnexin suppresses GD3 synthase-induced apoptosis. FASEB J 2004 Oct;18(13):1553-5. doi: 10.1096/fj.04-1675fje.

Sánchez-Alcázar JA, Schneider E, Hernández-Muñoz I, Ruiz-Cabello J, Siles-Rivas E, de la Torre P, Bornstein B, Brea-Calvo G, Arenas J, Garesse R, Solís-Herruzo JA, Knox AJ, Navas P. Reactive oxygen species mediate the down-regulation of mitochondrial transcripts and proteins by tumour necrosis factor-alpha in L929 cells. Biochem J. 2003 Mar 1;370:609-19. doi: 10.1042/BJ20021623.

Book chapters

Gloria Brea-Calvo, María Alcázar-Fabra, Eva Trevisson, and Plácido Navas (2021). Coenzyme Q Biosynthesis Disorders. In Mitochondrial Diseases Theory, Diagnosis and Therapy. Salviati and Navas eds. pp. 143-190. Springer Nature Switzerland.

López-Lluch G, Siendones E, Brea-Calvo G, Fernandez-Ayala DJM & Navas P (2008). Role of antioxidants in the therapy against leukemia. In New Research on Antioxidants.  Marín D & García P, eds, pp. 1-34. Nova Science Publishers, NY

Siendones E, Brea-Calvo G, Cascajo-Almenara MV, López-Lluch G, Sánchez-Alcázar JA, & Navas P (2006). The two faces of a same function: pro- and antiapoptotic role of Ubiquinone. In Frontiers in Cell Apoptosis Research (Erlich SR, ed), pp. 1-35. Nova Science Publishers, NY.